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Pancreatic cancer (PC) has a high fatality rate and is often diagnosed late. Obesity is a significant risk factor for PC, leading to inflammation and altered gut microbiota that may contribute to its development. Non-alcoholic fatty liver disease (NAFLD) is linked to obesity but its association with PC risk remains unclear. Both PC and NAFLD may share genetic factors, and research is ongoing to understand their underlying mechanisms through comprehensive sequencing data analysis. The study identified the shared genetic factor COL11A1 as a possible biomarker in PC and NAFLD. Notably, hsa-miR-29c-3p emerged as a promising prognostic biomarker targeting COL11A1 in PC, with implications for patient survival. These findings contribute to our understanding of the underlying mechanisms and may offer clinical significance in predicting outcomes and guiding therapeutic approaches for these challenging diseases.